Anti-S-100 (β-Subunit) antibody, Mouse monoclonal

Monoclonal Anti-S-100 (β-subunit) (mouse IgG1 isotype) is derived from the SH-B1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. S-100 is a set of small, thermolabile, highly acidic homo or hetero-dimer calcium binding proteins. The protein exists in two isoforms namely, S-100α and S-100β, which are brain specific.

S-100β is a calcium binding protein. It is mainly present in astrocytes and neurons of hindbrain and spinal cord.

Purified bovine brain S-100β

Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse has been used in:

• immunohistochemistry
• enzyme linked immunosorbent assay (ELISA) (Ca²⁺ ion independent)
• immunocytochemistry
• immunoblotting
• dot blot
• immunohistochemistry.

S-100β protein interacts with synaptic, cytoskeletal and cell cycle proteins. Additionally, it can regulate calcium levels in glial and neuronal cells. It is involved in neuronal plasticity, astrogliosis and neuronal cell survival. S-100β is associated with Alzheimer disease and amyotrophic lateral sclerosis.

S-100 is involved in cell-growth regulation, increasing membrane permeability to cations, inflammatory response in many brain diseases, including schizophrenia, stimulation of nucleolar RNA polymerase activity and transporting proteins and free fatty acids in adipocytes. S-100β tissue distribution can be a useful tool in the differential diagnosis of neoplasms and proliferative processes.

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