SAB4200703
Anti-Neurotensin/NTS antibody, Mouse monoclonal
clone NTS-11, purified from hybridoma cell culture
Synonym(s):
Anti- neurotensin, Anti-NMN125, Anti-NN, Anti-NT, Anti-NT/N
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About This Item
NACRES:
NA.44
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
NTS-11, monoclonal
Application:
IHC
Citations:
10
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
NTS-11, monoclonal
form
buffered aqueous solution
species reactivity
rat, human
concentration
~1 mg/mL
technique(s)
immunoblotting: 5-10 μg/mL using whole extract of SK-N-SH cells, immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded rat brain sections
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NTS(4922)
rat ... Nts(299757)
General description
Anti-Neurotensin/NTS antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the NTS-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide. Neurotensin (also known as NTS or NT) is a 13 amino acid brain-gut peptide.
Immunogen
Synthetic peptide from C-terminal region of human Neurotensin, conjugated to KLH
Application
Anti-Neurotensin/NTS antibody, Mouse monoclonal has been used in:
- immunoblotting
- immunohistochemistry
- immunofluorescence
Biochem/physiol Actions
Neurotensin (NTS) functions as a neurotransmitter/neuromodulator in the central nervous system (CNS) and as an endocrine agent in the gastrointestinal (GI) tract. Neurotensin is involved in a variety of physiological processes such as, stress and pain modulation, pathophysiology of drug addiction, schizophrenia, Parkinson disease, depression, locomotion and reward. In the brain, neurotensin modulates dopaminergic transmission in the nigrostriatal and mesocorticolimbic pathways as well as hormone secretion from the anterior pituitary.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Related Content
G S Katsanos et al.
International journal of immunopathology and pharmacology, 21(2), 255-259 (2008-06-13)
The tridecapeptide neurotensin (NT) acts in the mammalian brain as a primary neurotransmitter or neuromodulator of classical neurotransmitters. Morphological and functional in vitro and in vivo studies have demonstrated the existence of close interactions between NT and dopamine both in
Konstantinos Kalafatakis et al.
Regulatory peptides, 170(1-3), 7-17 (2011-05-10)
Among various hormones, which are synthesized by intestinal cells and influence enteric function, neurotensin (NT) has gained scientific attention the last three decades. This neuropeptide, mainly located in neuronal synaptic vesicles of hypothalamus and in neuroendocrine cells of the small
B Mark Evers
Peptides, 27(10), 2424-2433 (2006-08-15)
Neurotensin (NT) is a brain-gut tridecapeptide that functions as a neurotransmitter/neuromodulator in the central nervous system (CNS) and as an endocrine agent in the periphery. NT has numerous physiologic effects on multiple organs. This review will focus on the effects
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4200703-100UL | 04061838037732 |