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SAB4200721

Anti-GABA antibody, Mouse monoclonal

Name: Anti-GABA antibody, Mouse monoclonal
Brand: SIGMA

clone GB-69, purified from hybridoma cell culture

Synonym(s):

Mouse Anti-Gamma-aminobutyric acid

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Clone:

GB-69, monoclonal

Species reactivity:

rat, monkey, frog, mouse, human, gerbil

Application:

DB, ELISA, IF, IHC

Citations:

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Properties

biological source

mouse

Quality Level

200

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

GB-69, monoclonal

form

buffered aqueous solution

species reactivity

rat, monkey, frog, mouse, human, gerbil

concentration

~1.0 mg/mL

technique(s)

ELISA: suitable, dot blot: suitable, immunofluorescence: 5-10 μg/mL using human pancreatic tumor AsPC1 cell line, immunohistochemistry: 1-2.5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)
rhesus monkey ... Gabra1(574302)

Description

General description

Anti-GABA antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the GB-69 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified GABA conjugated to BSA. γ-Aminobutyric acid (GABA) is present in the central nervous system (CNS) of vertebrates. GABA is formed following enzymatic decarboxylation of L-glutamic acid by glutamic acid decarboxylase (GAD).

Immunogen

purified GABA conjugated to BSA

Application

Anti-GABA antibody, Mouse monoclonal has been used in:

immunofluorescence
immunohistochemistry
enzyme linked immunosorbent assay (ELISA)
dot-blot

Biochem/physiol Actions

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter. GABA mediates fast synaptic inhibition in the mature nervous system and plays multiple key roles as sensory circuits undergo functional development. GABA promotes proliferation of immune cells, embryonic stem cells and cortical progenitor cells. In addition, it is involved in protein synthesis and metabolism and plays a major role in the regulation of muscle tone, blood pressure, heart rate and respiration.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number

096M4788V

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Global Trade Item Number

SKU	GTIN
SAB4200721-100UL	04061838037770