SAB4200776
Anti-TUBA1A (TUBA3) Antibody
mouse monoclonal, TUB-1A2
Synonym(s):
Tubulin Alpha-1 Chain
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Clone:
TUB-1A2, monoclonal
Species reactivity:
Xenopus, Arabidopsis sp., yeast, insect, rat, hamster, porcine, monkey, bovine, human, mouse, canine, chicken
Application:
IF, IHC
Citations:
18
Product Name
Anti-Tubulin, Tyrosine antibody, Mouse monoclonal, clone TUB-1A2, purified from hybridoma cell culture
biological source
mouse
Quality Level
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
TUB-1A2, monoclonal
form
buffered aqueous solution
mol wt
~55 kDa
species reactivity
Xenopus, Arabidopsis sp., yeast, insect, rat, hamster, porcine, monkey, bovine, human, mouse, canine, chicken
concentration
~1 mg/mL
technique(s)
immunoblotting: suitable, immunofluorescence: 2-4 μg/mL using human HeLa or Chicken fibroblast cells, immunohistochemistry: suitable
isotype
IgG3
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TUBA1A(7846)
General description
Anti-Tubulin, Tyrosine antibody, Mouse monoclonal (mouse IgG3 isotype) is derived from the TUB-1A2 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from mouse. Tubulin is an intracellular cylindrical filamentous structure and is presented in eukaryotic cells. It consists of three isoforms α-, β- and γ-tubulin. Tubulin is a heterodimer of α- and β- tubulin subunits.
Immunogen
a synthetic peptide containing the carboxy terminal amino acids of porcine a-tubulin
Application
Anti-Tubulin, Tyrosine antibody, mouse monoclonal may be used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Biochem/physiol Actions
Anti-Tubulin, Tyrosine antibody, Mouse monoclonal specifically recognizes the C-terminal Tyrosine of Tubulin protein. The antibody is non-reactive with cells that have been treated with pancreatic carboxypeptidase A under conditions which remove only the C-terminal tyrosine. Monoclonal Anti-Tubulin, Tyrosine recognizes Tubulin from human, mouse, chicken, bovine, rat, hamster, canine, monkey, porcine, arabidopsis, tobacco, yeast, Xenopus, insect, comb jelly, sponge, and worm origin.
Tubulin is the major building block of microtubules which is essential for structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton. It is also involved in the nervous system. Tubulin is associated with neurodegenerative disorders such as Alzheimer′s and Parkinson′s disease. Mutations in the αβ- dimers and γ-tubulin are associated with malformation and impairment of cognitive disorders.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Related Content
D Boucher et al.
Biochemistry, 33(41), 12471-12477 (1994-10-18)
The multiple functions of microtubules are mediated by various structural and motor microtubule-associated proteins (MAPs). To harmonize these functions in different places of a single cell, the key problem is to regulate the interactions of these proteins with microtubules. The
Soumyananda Chakraborti et al.
Cytoskeleton (Hoboken, N.J.), 73(10), 521-550 (2016-10-19)
Across different cell types and tissues, microtubules are assembled from highly conserved dimers of α- and β-tubulin. Despite their highly similar structures, microtubules have functional heterogeneity, generated either by the expression of different tubulin genes, encoding distinct isotypes, or by
Jennetta W Hammond et al.
Current opinion in cell biology, 20(1), 71-76 (2008-01-30)
All microtubules are built from a basic alpha/beta-tubulin building block, yet subpopulations of microtubules can be differentially marked by a number of post-translational modifications. These modifications, conserved throughout evolution, are thought to act individually or in combination to control specific
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4200776-100UL | 04061833265314 |