SAB4301658
Anti-CSPG4 Antibody
rabbit polyclonal
Synonym(s):
HMW-MAA, MCSP, MCSPG, MSK16, NG2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
human, mouse, rat
Application:
IHC, WB
Citations:
8
Product Name
Anti-CSPG4, affinity isolated antibody
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human, mouse, rat
technique(s)
immunohistochemistry: 1:20-1:100, western blot: 1:500-1:2000
accession no.
NP_001888
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CSPG4(1464)
General description
Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4
Biochem/physiol Actions
Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.
Features and Benefits
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Physical form
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas
Eisenmann KM, et al.
Nature Cell Biology, 1(8), 507-513 (1999)
A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family
Staub E, et al.
Febs Letters, 527(1-3), 114-118 (2002)
Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma
Wang J, et al.
PLoS ONE, 6(7), e23062-e23062 (2011)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4301658-100UL | 04061835798377 |