Anti-Collagen Type II (COL2A1) Antibody

Anti-Collagen II Antibody detects endogenous levels of total Collagen II protein.

Collagen type II α 1 chain (COL2A1) gene is mapped to human chromosome 12q13.11–q13.12. COL2A1 belongs to collagen superfamily. The encoded protein is characterized with three identical α chains forming homotrimers. Collagen II is the major component of cartilage.

The antiserum was produced against synthesized peptide derived from human Collagen II.

Immunogen Range: 101-150

Anti-Collagen II, N-Terminal antibody produced in rabbit has been used for:

• Western blotting
• Immunofluorescence
• Immunohistological analyses

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (2 papers)

Mutation of collagen type II α 1 chain (COL2A1), leads to a variety of clinical manifestations such as skeletal dysplasia, short stature, and sensorial defects, collectively known as type II collagenopathies. Function of COL2A1 in articular cartilage is to form highly organized fibers, which are essential for the mechanical properties of the tissue.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.