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Merck
CN

SAB4501633

Anti-KCNJ5 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

G protein-activated inward rectifier potassium channel 4, GIRK4, Inward rectifier K(+) channel Kir3.4, Potassium channel, inwardly rectifying subfamily J member 5

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
3
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 47 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNJ5(3762)

General description

Anti-KCNJ5 Antibody detects endogenous levels of total KCNJ5 protein.
KCNJ5 (potassium voltage-gated channel subfamily J member 5) is an inwardly rectifying potassium channel, which is also termed as GIRK4 (G protein-coupled inward rectifier K+ channel 4). It is expressed in the cerebral cortex. This gene is mapped to human chromosome 11q24.

Immunogen

The antiserum was produced against synthesized peptide derived from human KCNJ5.

Immunogen Range: 370-419

Biochem/physiol Actions

KCNJ5 (potassium voltage-gated channel subfamily J member 5) is associated with aldosteronism, a major cause of secondary hypertension. Mutated KCNJ5 gene affects the polarization of plasma membrane and permit sodium and calcium inflow into the cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
常规特殊物品

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Positive association between KCNJ5 rs2604204 (A/C) polymorphism and plasma aldosterone levels, but also plasma renin and angiotensin I and II levels, in newly diagnosed hypertensive Chinese: a case-control study.
Wang H, et al.
Journal of Human Hypertension, 31(7), 457-461 (2017)
Potassium Channel Mutant KCNJ5 T158A Expression in HAC-15 Cells Increases Aldosterone Synthesis.
Kenji K, et al.
Endocrinology, 153(4), 1774?1782-1774?1782 (2012)
Significant linkage to migraine with aura on chromosome 11q24.
Zameel MC, et al.
Human Molecular Genetics, 12(19), 2511?2517-2511?2517 (2003)



Global Trade Item Number

SKUGTIN
SAB4501633-100UG04061837187629