Anti-INOS antibody produced in rabbit

Anti-INOS antibody detects endogenous levels of total INOS protein.

The INOS (inducible nitric oxide synthase) gene is mapped to human chromosome 17q11.2.

The antiserum was produced against synthesized peptide derived from human iNOS.

Immunogen Range: 1101-1150

Anti-INOS, C-Terminal antibody produced in rabbit has been used in immunoblotting.

Upregulation of INOS (inducible nitric oxide synthase) is observed during infections, tissue injury, and inflammation. INOS is responsible to produce NO (nitric oxide), which controls blood flow by inducing vascular relaxation. NO acts as a neurotransmitter and can facilitate immune responses. NO can also bring about anti-thrombotic and anti-inflammatory effects in response to oxidative stress, hypoxia, inflammatory cytokines (TNF-α, IL-1β, IFN-γ), and lipopolysaccharide endotoxin. iNOS generates more NO than the neuronal and endothelial NOS. Unlike the two isoforms, iNOS is calcium independent. INOS might be associated with type 2 diabetes mellitus.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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