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SAB5200113

Anti-Amyloid Precursor Protein (APP) Antibody

Name: Anti-Amyloid Precursor Protein (APP) Antibody
Brand: SIGMA

rabbit polyclonal

Synonym(s):

Anti-A11, Anti-Amyloid Oligomer αβ, Anti-Amyloid Oligomers (A11)

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, IP, WB

Citations:

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Properties

Product Name

Anti-APP antibody produced in rabbit, 1 mg/mL, affinity isolated antibody

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

mouse, eukaryotes, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable, western blot: suitable

NCBI accession no.

NM_000484.2

UniProt accession no.

P05067

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APP(351)

Description

General description

Amyloid β precursor protein (APP) is a type 1 transmembrane protein. The gene is located on human chromosome 21q21.3.

Immunogen

Synthetic molecular mimic of soluble oligomers.

Application

Anti-APP antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Amyloid β precursor protein (APP) regulates cell signaling. Mutation in this gene is associated with Alzheimer′s disease. It is implicated in synaptic plasticity, dendritic morphogenesis and neuroprotection. APP modulates synaptic vesicle proteins and synaptic transmission. It is involved in GABAergic transmission and maintains the excitatory/inhibitory (E/I) balance.

Amyloid precursor protein (APP) plays a key role in Wnt signalling. It helps to increase synaptoxicity, that is facilitated by Dickkopf-1 (Dkk1). Mutations on this gene results in autosomal dominant early-onset Alzheimer disease (ADEOAD)/hereditary dementia with cerebral amyloid angiopathy (CAA).

Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number

SPC-506D

1201

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Human brain-derived Abeta oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP

Wang Z, et al.

The Journal of Neuroscience, 37(49), 11947-11966 (2017)

Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24. 3

Elliott C, et al.

Translational Psychiatry, 2(4), 179-179 (2018)

Protective effects of sulforaphane on cognitive impairments and ad-like lesions in diabetic mice are associated with the upregulation of Nrf2 transcription activity

Pu D, et al.

Neuroscience, 381, 35-45 (2018)

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Global Trade Item Number

SKU	GTIN
SAB5200113-100UL	04061838059192