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Merck
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SAB5700440

Anti-Phospho-TP53-S33 antibody produced in rabbit

Synonym(s):

BCC7, BMFS5, LFS1, P53, TP53, TRP53, p53

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
mouse, human, rat
Application:
IHC, IP, WB
Citations:
-
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biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

23-43

species reactivity

mouse, human, rat

concentration

0.47 mg/ml

technique(s)

immunohistochemistry: 1:50-1:100, immunoprecipitation (IP): 1:50-1:100, western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer33)

Gene Information

human ... TP53(7157)

General description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Immunogen

A synthetic phosphorylated peptide around S33 of human p53 (NP_000537.3).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Preparation Note

Store at -20℃. Avoid freeze / thaw cycles.


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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

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Global Trade Item Number

SKUGTIN
SAB5700440-100UL04065265175852