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SML0077

VU591

≥98% (HPLC)

Synonym(s):

2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole

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About This Item

Empirical Formula (Hill Notation):
C16H12N6O5
CAS Number:
1222810-74-3
Molecular Weight:
368.30
UNSPSC Code:
12352200
PubChem Substance ID:
329825139
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥12 mg/mL

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1

InChI

1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)

InChI key

ZQPXNYLXYNRFNP-UHFFFAOYSA-N

Gene Information

human ... KCNJ1(3758)

Application

VU591 may be used in cell signaling studies.

Biochem/physiol Actions

ROMK (Kir 1.1) inhibitor
VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
071M4602V

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Articles

钾通道

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Potassium Channels

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Jiun-Lin Horng et al.
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Molecular mechanisms of Na

Global Trade Item Number

SKUGTIN
SML0077-25MG04061832575971
SML0077-5MG04061832575988