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SML0100

GYY4137 Dichloromethane complex

Name: GYY4137 Dichloromethane complex
Brand: SIGMA

≥98% (HPLC), powder, H₂S donor

Synonym(s):

P-(4-Methoxyphenyl)-P-4-morpholinyl-phosphinodithioic acid, compound with morpholine (1:1), morpholin-4-ium 4-methoxyphenyl(morpholino) phosphinodithioate dichloromethane complex

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₆NO₂PS₂ · C₄H₉NO · xCH₂Cl₂

CAS Number:

106740-09-4

Molecular Weight:

376.47

UNSPSC Code:

12352200

PubChem Substance ID:

329825158

NACRES:

NA.25

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

GYY4137 Dichloromethane complex, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥3 mg/mL

storage temp.

2-8°C

SMILES string

ClCCl.S=P(N1CCOCC1)([S-])C2=CC=C(OC)C=C2.C3COCC[NH2+]3

InChI

1S/C11H16NO2PS2.C4H9NO.CH2Cl2/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1;2-1-3/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2;1H2

InChI key

PKLNNEJKTAMITC-UHFFFAOYSA-N

Description

Application

GYY4137 Dichloromethane complex has been used as a non-isothiocyanate H2S (hydrogen sulfide) donor.

Biochem/physiol Actions

GYY4137 is a small molecule releaser of H₂S with vasodilator and antihypertensive activity. H₂S has been found to be an important biological mediator with multiple effects on neuromodulation, hypertension, inflammation, and vascular tone. GYY4137 should prove useful in the study of the many and varied biological effects of H₂S.

Small molecule releaser of H2S

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.

Ling Li et al.

Circulation, 117(18), 2351-2360 (2008-04-30)

The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years. The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] and evaluate its use as a

Effects of natural and synthetic isothiocyanate-based H

Lorenzo Di Cesare Mannelli et al.

Neuropharmacology, 121, 49-59 (2017-04-23)

Hydrogen sulfide (H

Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels.

Di Cesare Mannelli L et al.

Neuropharmacology, 121, 49-49 (2007)

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Global Trade Item Number

SKU	GTIN
SML0100-10MG	04061833027110
SML0100-50MG	04061837076855