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SML0309

Sodium phenylbutyrate

Name: Sodium phenylbutyrate
Brand: SIGMA

≥98% (HPLC), histone deacetylase inhibitor, powder

Synonym(s):

4-PBA, 4-Phenylbutyric acid, 4-phenylbutyrate, Buphenyl, Sodium 4-phenylbutyrate, TriButyrate

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₁NaO₂

CAS Number:

1716-12-7

Molecular Weight:

186.18

UNSPSC Code:

12352200

PubChem Substance ID:

329825314

NACRES:

NA.77

MDL number:

MFCD00800247

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

Sodium phenylbutyrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: ≥5 mg/mL

storage temp.

room temp

SMILES string

[Na+].[O-]C(=O)CCCc1ccccc1

InChI

1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1

InChI key

VPZRWNZGLKXFOE-UHFFFAOYSA-M

Description

General description

Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.

Application

Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Biochem/physiol Actions

Sodium phenylbutyrate is a histone deacetylase inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease (2008)

Advances in Clinical Chemistry, Volume 17 (2014)

Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control

Lee B, et al.

Molecular Genetics and Metabolism, 100(3), 221-228 (2010)

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Global Trade Item Number

SKU	GTIN
SML0309-100MG	04061837084171