SML0407
ML141
≥98% (HPLC)
Synonym(s):
4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C22H21N3O3S
CAS Number:
Molecular Weight:
407.49
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
ML 141, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (warmed, clear solution)
storage temp.
2-8°C
SMILES string
NS(C1=CC=C(C=C1)N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)(=O)=O
InChI
1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
InChI key
QBNZBMVRFYREHK-UHFFFAOYSA-N
Application
ML 141 has been used:
- to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
- as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
- as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
- as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells
Biochem/physiol Actions
ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42.
ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells
Takeuchi H, et al.
Cellular Microbiology, 18(7), 928-948 (2016)
Local arrangement of fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
Roman W, et al.
Developmental Cell, 46(1), 102-111 (2018)
Multiple routes of endocytic internalization of PDGFR beta contribute to PDGF-induced STAT3 signaling
Jastrzkebski K, et al.
Journal of Cell Science, 130(3), 577-589 (2017)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0407-5MG | 04061837084461 |
| SML0407-25MG | 04061833066478 |