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Merck
CN

SML0412

IM-54

≥98% (HPLC)

Synonym(s):

1-Methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione, 2-(1H-Indol-3-yl)-3-pentylamino-maleimide

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About This Item

Empirical Formula (Hill Notation):
C19H23N3O2
CAS Number:
Molecular Weight:
325.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Technical Service
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Quality Level

assay

≥98% (HPLC)

form

powder

color

light orange to dark orange

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

CCCCCNC1=C(C(=O)N(C)C1=O)c2cn(C)c3ccccc23

InChI

1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)22(3)19(17)24)14-12-21(2)15-10-7-6-9-13(14)15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3

InChI key

SGLOMINNEBLJFF-UHFFFAOYSA-N

Biochem/physiol Actions

IM-54 is a cell permeable, potent and selective inhibitor of necrosis.
IM-54 is a cell permeable, potent and selective inhibitor of necrosis. The compound inhibits necrosis induced by oxidative stress. IM-54 does not inhibit apoptosis induced by anticancer drugs.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Wen Sun et al.
Free radical biology & medicine, 108, 433-444 (2017-04-18)
Necroptosis is a form of programmed necrosis mediated by signaling complexes with receptor-interacting protein 1 (RIP1) and RIP3 kinases as the main mediators. However, the underlying execution pathways of this phenomenon have yet to be elucidated in detail. In this
Longhao Sun et al.
Autophagy, 13(4), 703-714 (2017-01-26)
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and lethal cancer. The role of autophagy in the pathobiology of PDAC is intricate, with opposing functions manifested in different cellular contexts. MIR506 functions as a tumor suppressor in many cancer types
Hexin Shi et al.
Nature communications, 12(1), 1379-1379 (2021-03-04)
Many immune responses depend upon activation of NF-κB, an important transcription factor in the elicitation of a cytokine response. Here we show that N4BP1 inhibits TLR-dependent activation of NF-κB by interacting with the NF-κB signaling essential modulator (NEMO, also known



Global Trade Item Number

SKUGTIN
SML0412-25MG04061833222706
SML0412-5MG04061833222713