SML0483
DpC
≥98% (HPLC)
Synonym(s):
Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone
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About This Item
Empirical Formula (Hill Notation):
C19H23N5S
CAS Number:
Molecular Weight:
353.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
−20°C
SMILES string
CN(C1CCCCC1)C(=S)N\N=C(\c2ccccn2)c3ccccn3
InChI
1S/C19H23N5S/c1-24(15-9-3-2-4-10-15)19(25)23-22-18(16-11-5-7-13-20-16)17-12-6-8-14-21-17/h5-8,11-15H,2-4,9-10H2,1H3,(H,23,25)
InChI key
GNLZNQJBZNOUBM-UHFFFAOYSA-N
Biochem/physiol Actions
DpC is an iron-chelating agent.
DpC is an iron-chelating agent. In four separate human pancreatic tumor cell lines, DpC significantly increased the expression and phosphorylation of the growth and metastasis suppressor, N-myc down-stream regulated gene 1 (NDRG1) and the cdk inhibitpr p21CIP1/WAF. DpC completely blocked PANC-1 tumor growth in mouse xenografts.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ruxing Xi et al.
Molecular pharmacology, 91(5), 499-517 (2017-03-10)
Tumor necrosis factor
Zaklina Kovacevic et al.
The Journal of biological chemistry, 291(3), 1029-1052 (2015-11-05)
N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-β pathway, protein kinase B (AKT)/PI3K pathway, RAS, etc. To investigate the hypothesis
Ye-Xing Xu et al.
Oncology letters, 15(5), 7999-8004 (2018-05-10)
The present study aimed to investigate the antitumor efficacy of di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) and di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) on head and neck squamous cell carcinoma (HNSCC) cells. The proliferation and apoptosis of HNSCC cells treated with the iron chelators DpC and Dp44mT were
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0483-25MG | 04061833066522 |
| SML0483-5MG | 04061833066539 |