SML0621
WZB117
≥98% (HPLC)
Synonym(s):
3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate), 3-Hydroxy-benzoic acid 1,1′-(3-fluoro-1,2-phenylene) ester
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About This Item
Empirical Formula (Hill Notation):
C20H13FO6
CAS Number:
Molecular Weight:
368.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
WZB-117, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC=CC(O)=C1)OC2=C(F)C=CC=C2OC(C3=CC(O)=CC=C3)=O
InChI
1S/C20H13FO6/c21-16-8-3-9-17(26-19(24)12-4-1-6-14(22)10-12)18(16)27-20(25)13-5-2-7-15(23)11-13/h1-11,22-23H
InChI key
FRSWCCBXIHFKKY-UHFFFAOYSA-N
Application
WZB-117 has been used to study its tumor initiating ability in cancer stem cells. It has also been used to study the effect of glucose antagonists on 2-NBDG (2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose) uptake.
Biochem/physiol Actions
WZB-117 is an irreversible inhibitor. In cancer cells, WZB-117 prevents cell growth by stimulating apoptosis in any glucose concentration. It targets self-renewal and tumor-initiating capacity in cancer stem cells.
WBZ 117 is an inhibitor of basal glucose transport in H1299 lung and other cancer cells.
WBZ 117 is an inhibitor of basal glucose transport.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors.
Mira A, et al.
Oncotarget, 8(24), 38193-38193 (2017)
Meng Wei et al.
Biochemical and biophysical research communications, 503(2), 1154-1159 (2018-06-29)
Like tumour cells, during intraerythrocytic stage, Plasmodium-infected erythrocytes rely completely on glucose absorption from the blood circulation for energy metabolism. Glucose is taken up by glucose transporter 1 (GLUT1) on human red blood cells (RBCs) and glucose transporter 4 (GLUT4)
Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs.
Cheng X T, et al.
Neural Plast., 2018, 7-7 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0621-25MG | 04061832633992 |
| SML0621-5MG | 04061837101182 |