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SML0956

Dexmedetomidine hydrochloride

Name: Dexmedetomidine hydrochloride
Brand: SIGMA

≥98% (HPLC), α2-adrenergic agonist , powder

Synonym(s):

(+)-Medetomidine hydrochloride, (S)-Medetomidine hydrochloride, 4-[(S)-α,2,3-Trimethylbenzyl]imidazole monohydrochloride, 5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₆N₂ · HCl

CAS Number:

145108-58-3

Molecular Weight:

236.74

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Product Name

Dexmedetomidine hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +48 to +58°, c = 1 in H₂O

storage condition

desiccated

color

white to beige

solubility

H₂O: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

[Cl-].[N+H2]1C=NC=C1[C@@H](C)c2c(c(ccc2)C)C

InChI

1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1

InChI key

VPNGEIHDPSLNMU-MERQFXBCSA-N

Description

Application

Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.

Biochem/physiol Actions

Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties, the (+)-isomer of medetomidine. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression.

Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H336,H411

pcodes

P261 - P264 - P271 - P273 - P301 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

026M4732V

024M4735V

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes

Ke Peng

Experimental and Therapeutic Medicine (2017)

Trained vs untrained evaluator assessment of body condition score as a predictor of percent body fat in adult cats.

Anna K Shoveller et al.

Journal of feline medicine and surgery, 16(12), 957-965 (2014-03-15)

Body condition scoring (BCS) provides a readily available technique that can be used by both veterinary professionals and owners to assess the body condition of cats, and diagnose overweight or underweight conditions. The objective of this study was to evaluate

3-Methyladenine and dexmedetomidine reverse lipopolysaccharide-induced acute lung injury through the inhibition of inflammation and autophagy

Dengfeng Ding

Experimental and Therapeutic Medicine, 15.4 (2018)

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Global Trade Item Number

SKU	GTIN
SML0956-10MG	04061832076812
SML0956-50MG	04061832076829