SML1187
Vacquinol-1 dihydrochloride
≥98% (HPLC)
Synonym(s):
2-(4-Chlorophenyl)-α−2-piperidinyl-4-quinolinemethanol dihydrochloride, NSC13316
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Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
Clc1ccc(cc1)c2nc3c(c(c2)C(O)C4NCCCC4)cccc3
InChI
1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2
InChI key
VKLJPGAHSLIQKH-UHFFFAOYSA-N
Biochem/physiol Actions
Vacquinol-1 dihydrochloride is potentially used as a therapeutic for Glioblastoma multiforme (GBM). This drug is highly stable in vivo, with a half-life in plasma of 52 hour. Vacquinol-1 has high oral bioavailability and good brain penetration.
Vacquinol-1 (NSC13316) is a brain penetrant inducer of catastrophic vacuolization in glioblastoma cells (GCs). Vacquinol-1 displays high cytotoxicity to GCs; it induces cell death by membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture of GCs. Vacquinol-1 originally was developed as an antimalarial compound.
Vacquinol-1 is a brain penetrant inducer of catastrophic vacuolization in glioblastoma cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Driving glioblastoma to drink.
Gilbertson R J.
Cell, 157(2), 289-290 (2014)
Gi Bum Kim et al.
Cell, 179(1), 251-267 (2019-09-21)
In situ transgenesis methods such as viruses and electroporation can rapidly create somatic transgenic mice but lack control over copy number, zygosity, and locus specificity. Here we establish mosaic analysis by dual recombinase-mediated cassette exchange (MADR), which permits stable labeling
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1187-25MG | 04061832926308 |
| SML1187-5MG | 04061832926315 |