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SML1195

Palonosetron hydrochloride

≥98% (HPLC)

Synonym(s):

(3aS)-2-[(3S)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride, (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-Benz[de]isoquinolin-1-one hydrochloride (1:1), RS 25259-197

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About This Item

Empirical Formula (Hill Notation):
C19H24N2O · HCl
CAS Number:
135729-62-3
Molecular Weight:
332.87
NACRES:
NA.77
PubChem Substance ID:
329825713
UNSPSC Code:
12352200
MDL number:
MFCD00939524
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated, protect from light
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Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -90 to -110°, c = 0.4 in H2O

storage condition

desiccated, protect from light

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1N([C@H]2C3CCN(CC3)C2)C[C@]4([H])C5=C1C=CC=C5CCC4.[H]Cl

InChI

1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1

InChI key

OLDRWYVIKMSFFB-SSPJITILSA-N

Gene Information

human ... HTR3A(3359)

Biochem/physiol Actions

Palonosetron is a potent and selective 5-HT3 receptor antagonist (Aloxi) used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
Palonosetron is a potent and selective 5-HT3 receptor antagonist.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
025M4743V

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Jing Ma et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 13560-13571 (2019-10-02)
So far, a comprehensive animal model that can mimic both the central and peripheral pathophysiological changes of irritable bowel syndrome (IBS) is lacking. Here, we developed a novel IBS rat model combining trinitro-benzene-sulfonic acid (TNBS) and chronic unpredictable mild stress

Global Trade Item Number

SKUGTIN
SML1195-10MG04061837107665
SML1195-50MG04061832077208