SML1246
JNK-IN-8
≥96% (HPLC), JNK inhibitor, powder
Synonym(s):
3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide
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About This Item
Empirical Formula (Hill Notation):
C29H29N7O2
CAS Number:
Molecular Weight:
507.59
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
JNK-IN-8, ≥96% (HPLC)
Quality Level
assay
≥96% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC(NC(C=CCN(C)C)=O)=CC=C1)NC(C=C2C)=CC=C2NC3=NC=CC(C4=CC=CN=C4)=N3
InChI
1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)
InChI key
GJFCSAPFHAXMSF-UHFFFAOYSA-N
Application
JNK-IN-8 has been used as an inhibitor to address the importance of JNK signaling in withaferin A (WFA)-induced apoptosis of myelodysplastic syndromes (MDS)-L cells.
Biochem/physiol Actions
JNK-IN-8 and lapatinib synergistically reduce cell viability in human triple negative breast cancers (TNBC) cell lines by inducing apoptosis. JNK-IN-8 and lapatinib result in accumulation of cytotoxic oxidative stress.
JNK-IN-8 is a potent, selective and irreversible inhibitor of JNK1/2/3 that inhibits phosphorylation of c-Jun. JNK-IN-8 forms covalent bonds with a conserved cysteine residue.
JNK-IN-8 is a potent, selective and irreversible inhibitor of JNK1/2/3.
Other Notes
JNK-IN-8 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the JNK-IN-8 probe summary on the Chemical Probes Portal website.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.
Ebelt ND, et al.
Oncotarget, 8(62), 104894-104894 (2017)
Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A
Oben KZ, et al.
Oncotarget, 8(44), 77436?77452-77436?77452 (2017)
Eugene Y Kim et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201800425R-fj201800425R (2018-05-26)
Rheumatoid arthritis (RA) is characterized by hyperplastic pannus formation mediated by activated synovial fibroblasts (RASFs) that cause joint destruction. We have shown earlier that RASFs exhibit resistance to apoptosis, primarily as a result of enhanced expression of myeloid cell leukemia-1
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1246-5MG | 04061832434681 |
| SML1246-25MG | 04061832434674 |