SML1291
Frovatriptan succinate monohydrate
≥97% (HPLC)
Synonym(s):
Frovatriptan succinate, R-(+) 3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole monosuccinate monohydrate
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About This Item
Empirical Formula (Hill Notation):
C14H17N3O · C4H6O4 · H2O
CAS Number:
Molecular Weight:
379.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(CCC(O)=O)=O.NC(C(C=C1)=CC2=C1NC3=C2C[C@H](NC)CC3)=O.O
InChI
1S/C14H17N3O.C4H6O4.H2O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8;/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8);1H2/t9-;;/m1../s1
InChI key
CUETXFMONOSVJA-KLQYNRQASA-N
Gene Information
human ... HTR1B(3351), HTR1D(3352)
Biochem/physiol Actions
During migraine condition, frovatriptan succinate monohydrate acts on extra cerebral, intracranial arteries and prevent excessive dilation of these vessels.
Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Frovatriptan has high affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower with a pEC50 value of 8.2 for the 5-HT1B receptor, compared to a pEC50 value of 6.2 for the 5-HT7 receptor.
Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Simple Spectrophotometric Method for Estimation of Frovatriptan Succinate in Bulk Drug and Pharmaceutical Formulation.
Nayak S, et al.
International Journal of Pharmaceutical Research and Allied Sciences, 4(2), 85-89 (2015)
Barbora Vyhlídalová et al.
International journal of molecular sciences, 21(8) (2020-04-23)
The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepatic and intestinal
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1291-10MG | 04061837107825 |
| SML1291-50MG | 04061832077307 |