SML2083
[Ala13]-Apelin-13 trifluoroacetate salt
≥96% (HPLC)
Synonym(s):
(F13A)apelin-13, Alanine apelin-13, Apelin-13(F13A), Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala TFA, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine TFA, QRPRLSHKGPMPA TFA, [Ala-13] apelin-13
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About This Item
Empirical Formula (Hill Notation):
C63H107N23O16S · xC2HF3O2
CAS Number:
Molecular Weight:
1474.73 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥96% (HPLC)
Form:
powder
assay
≥96% (HPLC)
form
powder
color
white to beige
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
(Ala13)-Apelin-13 corresponds to Apelin-13 with a Phe-to-Ala substitution at the C-terminus (F13A) and functions as an antagonist against apelin-dependent APJ functions both in cultures and in animal studies in vivo.
Apelin-13 with a Phe-to-Ala substitution at the C-terminus (F13A) and functions as an antagonist against apelin-dependent APJ functions.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Xue Han et al.
Atherosclerosis, 244, 1-8 (2015-11-19)
Vascular calcification (VC) is closely related to cardiovascular events in chronic kidney disease (CKD). Apelin has emerged as a potent regulator of cardiovascular function, but its role in VC during CKD remains unknown. We determined whether apelin plays a role
Frédéric Adam et al.
Blood, 127(7), 908-920 (2015-12-05)
Apelin peptide and its receptor APJ are directly implicated in various physiological processes ranging from cardiovascular homeostasis to immune signaling. Here, we show that apelin is a key player in hemostasis with an ability to inhibit thrombin- and collagen-mediated platelet
Anne Drougard et al.
Antioxidants & redox signaling, 20(4), 557-573 (2013-07-25)
We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) and physiological (normal versus diabetic) states. An intracerebroventricular (icv) injection of a high dose of apelin
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2083-1MG | 04061835492756 |
| SML2083-5MG | 04061835492763 |