SML2911
dBRD9 Hydrochloride
≥97% (HPLC)
Synonym(s):
2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide Hydrochloride, Naphthiridinone degrader 6 Hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C40H45N7O10 · xHCl
Molecular Weight:
783.83 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
ligand
pomalidomide
Quality Level
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
cell permeable, potent and selective BRD9-directed chemical degrader
dBRD9 is a cell permeable, potent and selective BRD9-directed chemical degrader that bridges the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex. dBRD9 exhibits a potent anti-proliferative activity in human AML lines.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Brittany C Michel et al.
Nature cell biology, 20(12), 1410-1420 (2018-11-07)
Mammalian SWI/SNF chromatin remodelling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex (ncBAF). However, their complex-specific targeting on chromatin, functions and roles in disease remain largely undefined. Here, we comprehensively mapped
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2911-1MG | 04061842701636 |
| SML2911-5MG | 04061842701643 |