SML3193
(S)-GSK2920487A
≥98% (HPLC)
Synonym(s):
(S)-(4-fluorobenzo[b]thiophen-2-yl)(3-(5-methyl-1H-imidazol-1-yl)piperidin-1-yl)methanone, (S)-1, TCMDC-143498
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About This Item
Empirical Formula (Hill Notation):
C18H18FN3OS
Molecular Weight:
343.42
UNSPSC Code:
51111800
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to gray
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(N1C[C@H](CCC1)N2C=CN=C2C)C3=CC4=C(S3)C=CC=C4F
InChI
1S/C18H18FN3OS/c1-12-20-7-9-22(12)13-4-3-8-21(11-13)18(23)17-10-14-15(19)5-2-6-16(14)24-17/h2,5-7,9-10,13H,3-4,8,11H2,1H3/t13-/m0/s1
InChI key
SBZYUUGJHIROPT-ZDUSSCGKSA-N
Biochem/physiol Actions
(S)-GSK2920487A is a promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani. (S)-GSK2920487A induces the accumulation of the 2,3-oxidosqualene, a substrate of OSC, in promastigotes and cell-free membrane preparations. It is active against axenic and intramacrophage amastigotes. Also, GSK2920487A is active against intracellular T. cruzi.
promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3193-25MG | 04065267044439 |
| SML3193-5MG | 04065267044446 |