SRE0069
Phosphoglucomutase from rabbit muscle
Synonym(s):
α-D-Glucose-1,6-bisphosphatase, α-D-Glucose-1-phosphate phosphotransferase
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About This Item
CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.32
MDL number:
Specific activity:
≥100 units/mg protein
form
lyophilized powder
Quality Level
specific activity
≥100 units/mg protein
foreign activity
Lactic dehydroenase ≤0.5%, Phosphoglucose Isomerase ≤0.01%, pyruvate kinase ≤0.05%
shipped in
wet ice
storage temp.
−20°C
General description
Research area: CellSignalling. The phosphoglucomutase (PGM) molecule, a single polypeptide chain, is made up of four α/β domains. The domains form a compact heart-shaped structure with a large fissure between the two lobes, and the molecule comprises about 40 secondary structural components. The active enzymatic site of the molecule is located at the bottom of the crevice on the surface of domain I. Rabbit muscle phosphoglucomutase (RB-PGM) is a monomer with a unique four-domain architecture.
Application
Phosphoglucomutase from rabbit muscle may be used in dephosphorylation to investigate the hexose bisphosphate activation of phosphoglucomutase.
Biochem/physiol Actions
Phosphoglucomutase (PGM) mainly catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate via a glucose 1,6-diphosphate intermediate. Hence it plays a key role in glycolysis and gluconeogenesis.
Physical form
Lyophilized powder containing Tris HCl, EDTA, magnesium acetate and carbohydrate
Other Notes
One unit will convert 1.0 μmole of α-D-glucose 1-phosphate to α-D-glucose 6-phosphate per min at pH 7.4 at 30 °C.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
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S Levin et al.
Protein engineering, 12(9), 737-746 (1999-10-03)
Three-dimensional structural models of three members of the phosphoglucomutase (PGM) superfamily, parafusin, phosphoglucomutase-related protein and sarcoplasmic reticulum phosphoglucomutase, were constructed by homology modeling based on the known crystal structure of rabbit muscle phosphoglucomutase. Parafusin, phosphoglucomutase-related protein and sarcoplasmic reticulum phosphoglucomutase
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRE0069-10KU | 04061833236802 |
| SRE0069-1KU | 04061826704080 |