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SRP5131

SMAD2, GST tagged human

Name: SMAD2, GST tagged human
Brand: SIGMA

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

JV18, JV18-1, MADH2, MADR2, MGC22139, MGC34440, hMAD-2, hSMAD2

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About This Item

CAS Number:

253862-89-4

NACRES:

NA.32

UNSPSC Code:

12352200

Form:

buffered aqueous glycerol solution

Assay:

≥70% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in E. coli

Mol wt:

~90 kDa

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Properties

biological source

human

recombinant

expressed in E. coli

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~90 kDa

NCBI accession no.

NM_001003652

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SMAD2(4087)

Description

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class

10 - Combustible liquids

wgk

WGK 1

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

G214-1

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Signaling of transforming growth factor-beta family members through Smad proteins.

Itoh S

European Journal of Biochemistry (2000)

Alterations in the Smad pathway in human cancers.

Samanta D and Datta PK

Frontiers in Bioscience (Landmark Edition) (2012)

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.

K Eppert et al.

Cell, 86(4), 543-552 (1996-08-23)

The MAD-related (MADR) family of proteins are essential components in the signaling pathways of serine/threonine kinase receptors for the transforming growth factor beta (TGFbeta) superfamily. We demonstrate that MADR2 is specifically regulated by TGFbeta and not bone morphogenetic proteins. The

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Global Trade Item Number

SKU	GTIN
SRP5131-50UG	04061832942490