T123
Thioperamide maleate salt
≥98% (HPLC), histamine H3 receptor antagonist, solid
Synonym(s):
MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C15H24N4S · C4H4O4
CAS Number:
Molecular Weight:
408.52
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Thioperamide maleate salt, solid
assay
≥98% (HPLC)
Quality Level
form
solid
storage condition
desiccated, under inert gas
color
white
solubility
H2O: >10 mg/mL, DMSO: 12 mg/mL, ethanol: 3 mg/mL
SMILES string
OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
InChI
1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
REZRBLGMJZZSID-BTJKTKAUSA-N
Gene Information
human ... HRH3(11255)
Application
Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.
Biochem/physiol Actions
Potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier.
Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
H Yokoyama et al.
European journal of pharmacology, 234(1), 129-133 (1993-03-30)
The effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions was studied in mice. Thioperamide significantly and dose dependently decreased the duration of each phase of convulsion and raised the electroconvulsive threshold. Its anticonvulsant effects were prevented
Toshiaki Matsutomo et al.
Journal of pharmaceutical and biomedical analysis, 168, 148-154 (2019-02-27)
Our previous study has shown that a single dose of S-1-propenylcysteine (S1PC) exerted an antihypertensive effect in spontaneously hypertensive rats (SHR), while its mode of action remained to be further investigated. The aim of this study was to explore the
Jiao Shen et al.
Neuroscience letters, 444(2), 166-171 (2008-08-30)
Previously, we showed that orexin-A, a 33-aa peptide, influences renal sympathetic nerve activity. Because the autonomic nervous system plays an important role in the regulation of lipid metabolism, we investigated the in vivo effects of orexin-A on the sympathetic nerve
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T123-100MG | 04061832093826 |
| T123-10MG | 04061837336874 |
| T123-25MG | 04061837336881 |