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T1512

Tetramisole hydrochloride

powder, ≥99% (TLC)

Synonym(s):

(±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H12N2S · HCl
CAS Number:
5086-74-8
Molecular Weight:
240.75
NACRES:
NA.77
PubChem Substance ID:
24278725
UNSPSC Code:
12352202
EC Number:
225-799-5
MDL number:
MFCD00005536
Beilstein/REAXYS Number:
4358989
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Product Name

Tetramisole hydrochloride, phosphatase inhibitor

biological source

synthetic (organic)

Quality Level

200

description

alkaline phosphatase inhibitor

assay

≥99% (TLC)

form

powder

mp

266-267 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

Cl[H].C1CN2CC(N=C2S1)c3ccccc3

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H

InChI key

LAZPBGZRMVRFKY-UHFFFAOYSA-N

Application

Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors.
Suitable for inhibition of various mammalian alkaline phosphatases (i.e., liver, kidney, placenta, bone and tumor). Intestinal alkaline phosphatases are only slightly inhibited.

Other Notes

Racemic form of levamisole.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBB6382V
030M5314V
030M5314
030M5312
108K5303

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Kinetics and inhibition of alkaline phosphatases from canine tissues.
H Van Belle
Biochimica et biophysica acta, 289(1), 158-168 (1972-11-10)
Karla Opperman et al.
Genetics, 199(2), 497-509 (2014-12-10)
The L1CAM family of cell adhesion molecules is a conserved set of single-pass transmembrane proteins that play diverse roles required for proper nervous system development and function. Mutations in L1CAMs can cause the neurological L1 syndrome and are associated with
Mariana G Simões et al.
BMC developmental biology, 14, 49-49 (2015-01-01)
Zebrafish are able to regenerate many of its tissues and organs after damage. In amphibians this process is regulated by nerve fibres present at the site of injury, which have been proposed to release factors into the amputated limbs/fins, promoting
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Global Trade Item Number

SKUGTIN
T1512-5G04061837337697
T1512-10G04061833632253
T1512-2G04061833632260