T2320
T0901317
≥98%
Synonym(s):
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C17H12NSO3F9
CAS Number:
Molecular Weight:
481.33
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Assay:
≥98%
Quality level:
Quality Level
assay
≥98%
mol wt
481.3
storage temp.
−20°C
SMILES string
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F
InChI
1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChI key
SGIWFELWJPNFDH-UHFFFAOYSA-N
Gene Information
human ... ABCA1(19), NR1H2(7376), NR1H3(10062)
Application
T0901317 has been used in LXR agonist study in order to observe the expression of all dietary cholesterol-regulated genes in mice. It has also been used to stimulate the radiolabeled peritoneal macrophages from WT (wildtype) and Tg (transgenic) mice for cellular cholesterol efflux assay.
Biochem/physiol Actions
T0901317 can prevent the secretion of insulin by acting on the metabolism of mitochondria.
LXR agonist whose treatment results in an LXR-dependent up-regulation of ABC1 gene expression
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Yan Xing et al.
Scientific reports, 6, 21309-21309 (2016-02-19)
Liver X receptors (LXRs) play essential roles in lipogenesis, anti-inflammatory action and hepatic stellate cells (HSCs) activation in the liver. However, the effects of LXRs on the capillarization of liver sinusoidal endothelial cells (LSECs) in liver fibrosis remain undetermined. Here
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
Maxwell KN, et al.
Journal of Lipid Research, 44(11), 2109-2119 (2003)
Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis
Yamada S, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(5), 994-1006 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T2320-10MG | 04061841248552 |
| T2320-5MG | 04061837341977 |