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Merck
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T3309

Transferrin human

≥98%

Synonym(s):

Siderophilin, partially saturated

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About This Item

CAS Number:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
eCl@ss:
34058011
Form:
powder
Assay:
≥98%
Biological source:
human
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biological source

human

Quality Level

assay

≥98%

form

powder

Iron content

300-600 ppm

technique(s)

cell culture | stem cell: suitable

impurities

≤1.0 EU/mg endotoxin

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... TF(7018)

General description

Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

Application

Transferrin has been used:
  • in isolation of epidermal stem cells and cell expansion
  • to study the effect of compound treatment on transferrin uptake
  • for transferrin uptake and confocal imaging

Biochem/physiol Actions

Transferrin facilitates the transfer of iron to erythron and peripheral tissues. Mutations in this gene is associated with atransferrinemia. Transferrin is required for fetal development. It is non immunogenic and transferrin-conjugated drugs inhibits cardiotoxicity and drug resistance.
Transferrin was shown to promote the proliferation of human lymphocytes. This effect is directly proportional to the level of iron present.

Analysis Note

Purity by agarose electrophoresis.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.


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Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

高风险级别生物产品--人源产品

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TFRC (transferrin receptor (p90, CD71))
Dorak MT
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
Nutritional issues in the patient with diabetes and foot ulcers
LITCHFORD MD
Levin and O'Neal's The Diabetic Foot, 199-217 (2008)
Influence of tobacco smoking on transferrin sialylation during pregnancy in smoking and non-smoking women with iron deficiency
Wrzesniak M, et al.
Environmental Toxicology and Pharmacology, 46, 95-102 (2016)



Global Trade Item Number

SKUGTIN
T3309-100MG04061837344183
T3309-1G04061826694565
T3309-500MG04061837344190