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CN

T3705

Transferrin human

Optiferrin, recombinant, expressed in rice

Synonym(s):

Optiferrin

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About This Item

CAS Number:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
eCl@ss:
34058011
Form:
powder
Assay:
≥95% (agarose gel electrophoresis)
Biological source:
human
Recombinant:
expressed in rice
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biological source

human

Quality Level

recombinant

expressed in rice

assay

≥95% (agarose gel electrophoresis)

form

powder

composition

Protein, ≥90%

Iron content

≥300 μg/g

technique(s)

immunoprecipitation (IP): suitable, tissue culture: suitable

impurities

≤1.0 EU/mg Endotoxin

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... TF(7018)

General description

Transferrin is an 80 kDa serum glycoprotein, which is expressed in hepatocytes. The gene is located on human chromosome 3q22.1.
Optiferrin is recombinant human transferrin that is completelyblood-free. Optiferrin’s performance is equivalent to human holo transferrin incell culture and offers significant regulatory advantages due to its safety andconsistency. Optiferrin is suitable for a broad range of cell types thatinclude stem, primary, and bioproduction cells.

Application

Transferrin Human has been used to perform immunoprecipitation measurements. It has also been used for the preparation of essential 8 medium.

Biochem/physiol Actions

Transferrin facilitates the transfer of iron to erythron and peripheral tissues. It stimulates the proliferation of human lymphocytes. Mutations in this gene are linked to atransferrinemia.
Human transferrin was shown to promote allogeneic chimerism in mice after irradiation and transplantation of incompatible bone marrow.

Other Notes

1). Patent Rights
U.S. Patent No. 9,321,828
2). Registered Trademark Rights
U.S. Reg. 3,880,881
International Reg. 1,466,509

Legal Information

rhTF manufactured in the USA by InVitria US Pat 9321828
Optiferrin is a trademark of InVitria


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis
Tolosano E
The Hematology Journal : The Official Journal of the European Haematology Association / EHA (2015)
Effect of human transferrin on the engraftment of allogeneic bone marrow in various strans of lethally irradiated mice.
Pierpaoli W.
Nature Immunology, 11, 356-365 (1992)
Effect of transferrin, lactoferrin and chelated iron on human T-lymphocytes
Djeha A and Brock JH
British Journal of Haematology, 80(2), 235-241 (1992)



Global Trade Item Number

SKUGTIN
T3705-5G04061837344961
T3705-1G04061837344954