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T4321

L-Tyrosine

Synonym(s):

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid, 3-(4-Hydroxyphenyl)-L-alanine

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About This Item

Linear Formula:
4-(HO)C6H4CH2CH(NH2)CO2H
CAS Number:
60-18-4
Molecular Weight:
181.19
EC Number:
200-460-4
UNSPSC Code:
12352209
eCl@ss:
32160406
Beilstein/REAXYS Number:
392441
MDL number:
MFCD00002606
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biological source

non-animal source

Quality Level

400

assay

≥99%

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

>300 °C (dec.) (lit.)

solubility

1 M HCl: 25 mg/mL

application(s)

pharmaceutical (small molecule)

foreign activity

cytotoxicity, tested

SMILES string

N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

InChI key

OUYCCCASQSFEME-QMMMGPOBSA-N

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to documentation for this product requires a confidentiality disclosure agreement.

Application

L-Tyrosine is a non-essential amino acid with a polar side group. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Other Notes

Amino acid precursor of dopamine and other catecholamines

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
CDBF8259
CDBF7875
CDBF7876
CDBF7534
CDBF7535

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Articles

L-Tyrosine in Cell Culture

Learn more about the amino acid L-Tyrosine and explore how it is used in cell culture media like MEM, DMEM, and RPMI. We offer a comprehensive portfolio of amino acid cell culture supplements and reagents.

Keisuke Saito et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7690-7695 (2013-04-20)
Using quantum mechanics/molecular mechanics calculations and the 1.9-Å crystal structure of Photosystem II [Umena Y, Kawakami K, Shen J-R, Kamiya N (2011) Nature 473(7345):55-60], we investigated the H-bonding environment of the redox-active tyrosine D (TyrD) and obtained insights that help
Hideki Hara et al.
Nature immunology, 14(12), 1247-1255 (2013-11-05)
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases Syk and Jnk were required for the activation of caspase-1 via the ASC-dependent inflammasomes NLRP3 and AIM2.
Alena Volgusheva et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7223-7228 (2013-04-17)
Photobiological H2 production is an attractive option for renewable solar fuels. Sulfur-deprived cells of Chlamydomonas reinhardtii have been shown to produce hydrogen with the highest efficiency among photobiological systems. We have investigated the photosynthetic reactions during sulfur deprivation and H2
View All Related Papers

Global Trade Item Number

SKUGTIN
T4321-100G04061834354789
T4321-10KG04061834432609
T4321-1KG04061837345722
T4321-25KG04061834432616