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T4509

4-Thiouridine

Name: 4-Thiouridine
Brand: SIGMA

≥98%, synthetic (organic), powder

Synonym(s):

4sU, RNA synthesis inhibitor, Thiouridine

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂N₂O₅S

CAS Number:

13957-31-8

Molecular Weight:

260.27

NACRES:

NA.51

PubChem Substance ID:

24900212

UNSPSC Code:

41106305

EC Number:

237-735-3

MDL number:

MFCD00006538

Assay:

≥98%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 20 mg/mL, clear

Storage temp.:

−20°C

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Properties

Product Name

4-Thiouridine, ≥98%

biological source

synthetic (organic)

Quality Level

200

assay

≥98%

form

powder

solubility

water: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=S)NC2=O

InChI

1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1

InChI key

ZLOIGESWDJYCTF-XVFCMESISA-N

Description

General description

4-Thiouridine is a photoreactive uridine analog.

Application

4-Thiouridine has been used in labeling and isolation of nascent RNAs.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Regulation of Intronic Polyadenylation by PCF11 Impacts mRNA Expression of Long Genes.

Ruijia Wang et al.

Cell reports, 26(10), 2766-2778 (2019-03-07)

Regulation of cleavage and polyadenylation (CPA) affects gene expression and polyadenylation site (PAS) choice. Here, we report that the CPA and termination factor PCF11 modulates gene expression on the basis of gene size. Although downregulation of PCF11 leads to inhibition

Ultrashort and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution.

Lukas Windhager et al.

Genome research, 22(10), 2031-2042 (2012-04-28)

RNA synthesis and decay rates determine the steady-state levels of cellular RNAs. Metabolic tagging of newly transcribed RNA by 4-thiouridine (4sU) can reveal the relative contributions of RNA synthesis and decay rates. The kinetics of RNA processing, however, had so

The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.

Indira Memet et al.

Nucleic acids research, 45(9), 5359-5374 (2017-01-25)

In eukaryotes, the synthesis of ribosomal subunits, which involves the maturation of the ribosomal (r)RNAs and assembly of ribosomal proteins, requires the co-ordinated action of a plethora of ribosome biogenesis factors. Many of these cofactors remain to be characterized in

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Global Trade Item Number

SKU	GTIN
T4509-25MG	04061837346200
T4509-100MG	04061837346156
T4509-250MG	04061837346194