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T6950

Tizanidine hydrochloride

≥98% (HPLC), powder

Synonym(s):

5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H9Cl2N5S
CAS Number:
64461-82-1
Molecular Weight:
290.17
NACRES:
NA.77
PubChem Substance ID:
24724634
UNSPSC Code:
12352200
MDL number:
MFCD00798231
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: >20 mg/mL

originator

Acorda Therapeutics

SMILES string

Cl[H].Clc1ccc2nsnc2c1NC3=NCCN3

InChI

1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H

InChI key

ZWUKMNZJRDGCTQ-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Application

Tizanidine hydrochloride has been used for developing spectrophotometric methods for the validation of skeletal muscle relaxants.

Biochem/physiol Actions

α2-adrenoceptor agonist.
Tizanidine hydrochloride is known to function as a skeletal muscle relaxant that acts centrally. Furthermore, this relaxant functions at spinal and supraspinal levels to block excitatory interneurons. This drug is used for the symptomatic relief of spasticity and painful muscle spasms.

Features and Benefits

This compound was developed by Acorda Therapeutics. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Tizanidine hydrochloride is soluble in water at a concentration that is greater than 20 mg/ml.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
063M4744V
051M4717V
127K47002V
127K47001
127K4700

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Tomoyuki Kawamata et al.
Anesthesiology, 98(6), 1480-1483 (2003-05-27)
Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation. Intrathecal tizanidine, another alpha(2)-adrenergic agonist, has provided antinociception without producing pronounced hemodynamic changes in animal studies. However, it has been
Mohamed I Walash et al.
Chemistry Central journal, 5, 60-60 (2011-10-11)
A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate (II) in pharmaceutical formulations. The proposed method is based on the formation of a

Global Trade Item Number

SKUGTIN
T6950-10MG04061832094090
T6950-50MG04061832086224