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T9034

Taurocholic acid sodium salt hydrate

BioXtra, ≥95% (HPLC)

Synonym(s):

2-[(3α,7α,12α-Trihydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid, 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Sodium taurocholate hydrate

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About This Item

Empirical Formula (Hill Notation):
C26H44NNaO7S · xH2O
CAS Number:
345909-26-4
Molecular Weight:
537.68 (anhydrous basis)
NACRES:
NA.21
PubChem Substance ID:
24278230
UNSPSC Code:
12161900
EC Number:
205-653-7
MDL number:
MFCD00150819
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biological source

synthetic (organic)

Quality Level

200

description

anionic

product line

BioXtra

assay

≥95% (HPLC)

form

powder

mol wt

micellar avg mol wt 2100

aggregation number

4

impurities

≤0.005% Phosphorus (P), ≤0.1% Insoluble matter

CMC

3-11 mM (20-25°C)

solubility

H2O: 0.2 M, clear, colorless to faintly yellow

anion traces

chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.01%, Mg: ≤0.005%, NH4+: ≤0.1%, Pb: ≤0.001%, Zn: ≤0.0005%

application(s)

detection

functional group

sulfonic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].[H]O[H].[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@H](CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCS([O-])(=O)=O

InChI

1S/C26H45NO7S.Na.H2O/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;;/m1../s1

InChI key

RDAJAQDLEFHVNR-NEMAEHQESA-M

Application

Anionic detergent used for protein solubilization.
Taurocholic acid, a bile acid, may be used in studies of the physiological effects of bile salts on intestinal function and bacterial flora development.

Biochem/physiol Actions

Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na(+)/taurocholate cotransporter (NTCP) and MRP3 into the hepatic carnalicular.
Non-sulfated bile salt.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL0304
SLCF5052
SLCC0785
SLBJ2325V
SLBT9650

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Mehmet Ali Kosekli et al.
Revista da Associacao Medica Brasileira (1992), 65(2), 204-210 (2019-03-21)
The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor α, on experimentally induced acute pancreatitis (AP) were examined. Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no
M-K Choi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 39(2), 171-181 (2009-03-04)
1. The purpose of this study was to investigate the involvement of rat Mrp2 and human MRP2 in benzylpenicillin transport using canalicular liver plasma membrane (cLPM) vesicles isolated from Sprague-Dawley or Easai hyperbilirubinemic (EHBR) rats, and MDCKII cells overexpressing MRP2.
Y Sai et al.
Journal of cell science, 112 ( Pt 24), 4535-4545 (1999-11-27)
The bile canalicular membrane contains several ATP-dependent transporters that are involved in biliary secretion. Canalicular transporters are synthesized in ER, modified in Golgi and transported to the apical plasma membrane. However, the route and regulation of intracellular trafficking of ATP-dependent
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Global Trade Item Number

SKUGTIN
T9034-100G04061833319116
T9034-1G04061837380426
T9034-25G04061833625095
T9034-5G04061833614174