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T9250

Thymidine

Name: Thymidine
Brand: SIGMA

≥99%, synthetic (organic), powder

Synonym(s):

1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil, 1-(2-Deoxy-β-D-ribofuranosyl)thymine, 2′-Deoxythymidine, Thymine deoxyriboside, dT

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₂O₅

CAS Number:

50-89-5

Molecular Weight:

242.23

NACRES:

NA.51

PubChem Substance ID:

24900588

UNSPSC Code:

41106305

EC Number:

200-070-4

MDL number:

MFCD00006537

Beilstein/REAXYS Number:

89285

Assay:

≥99%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 50 mg/mL, clear, colorless

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Properties

Product Name

Thymidine, ≥99%

biological source

synthetic (organic)

Quality Level

300

assay

≥99%

form

powder

mp

186-188 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1

InChI key

IQFYYKKMVGJFEH-XLPZGREQSA-N

Gene Information

human ... DTYMK(1841)

Description

General description

Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine. It is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.

Application

Thymidine has been used:

as a supplement in HL5-modified medium for cell culture
to incubate cells in cell-cycle analysis
in cell synchronization

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase

Lee KJ, et al.

Nucleic Acids Research, 44(4), 1732-1745 (2015)

Molecular Biology, Principles of Genome Function: Biology, Molecular biology (2016)

Human Biochemistry and Disease, 571-571 (2008)

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Global Trade Item Number

SKU	GTIN
T9250-1G	04061835559398
T9250-10G	04061835546442
T9250-25G	04061837380891
T9250-5G	04061835518531