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U2625

Uric acid

Name: Uric acid
Brand: SIGMA

≥99%, crystalline

Synonym(s):

2,6,8-Trihydroxypurine

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About This Item

Empirical Formula (Hill Notation):

C₅H₄N₄O₃

CAS Number:

69-93-2

Molecular Weight:

168.11

UNSPSC Code:

12352005

NACRES:

NA.55

PubChem Substance ID:

24900634

EC Number:

200-720-7

Beilstein/REAXYS Number:

156158

MDL number:

MFCD00005712

Assay:

≥99%

Form:

crystalline

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Properties

Quality Level

100, 200

assay

≥99%

form

crystalline

mp

>300 °C (lit.)

SMILES string

O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

InChI key

LEHOTFFKMJEONL-UHFFFAOYSA-N

Description

Application

Uric acid has been used:

in inducing hyperuricemia in mice
as a component of digestion fluid for the simulation of in vitro human digestion model
in selectivity test of the glucose sensor in sweat-based diabetes monitoring

Biochem/physiol Actions

Uric acid is an insoluble catabolite produced by adenine and guanine metabolism. Accumulation of uric acid leads to gout, hyperuricemia, arthritis and renal failure. Elevated uric acid levels contributes to hypertension and pathogenesis of cardiovascular disease. Low uric acid levels associated with Parkinson′s disease and multiple sclerosis, may elicit protective functionality. High levels of uric acid in patients with chronic obstructive pulmonary disease (COPD) may serve as potential marker for diagnosis.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Uric Acid in Cell Culture

Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.

Serum uric acid as a predictor of mortality and future exacerbations of COPD

Bartziokas K, et al.

The European Respiratory Journal, 43(1), 43-53 (2014)

Uric acid, hyperuricemia and vascular diseases

Jin M, et al.

Frontiers in Bioscience, 17, 656-656 (2012)

A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy

Lee H, et al.

Nature Nanotechnology, 11(6), 566-566 (2016)

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Global Trade Item Number

SKU	GTIN
U2625-1KG	04061835550418
U2625-100G	04061835550401
U2625-25G	04061835550425