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U6381

Uridine

Name: Uridine
Brand: SIGMA

≥99%, synthetic (organic), powder

Synonym(s):

1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂N₂O₆

CAS Number:

58-96-8

Molecular Weight:

244.20

NACRES:

NA.26

PubChem Substance ID:

24900434

UNSPSC Code:

12352204

EC Number:

200-407-5

MDL number:

MFCD00006526

Beilstein/REAXYS Number:

754902

Assay:

≥99%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

H₂O: 0.1 M, clear, colorless

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Properties

Product Name

Uridine, BioUltra, ≥99%

Quality Level

200

biological source

synthetic (organic)

product line

BioUltra

assay

≥99%

form

powder

impurities

≤0.016% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.2%

mp

163-167 °C (lit.)

solubility

H₂O: 0.1 M, clear, colorless

cation traces

Al: ≤0.0005%, Ca: ≤0.01%, Cu: ≤0.0005%, Fe: ≤0.003%, K: ≤0.005%, Mg: ≤0.003%, NH₄⁺: ≤0.15%, Na: ≤0.02%, Pb: ≤0.005%, Zn: ≤0.0005%

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

InChI key

DRTQHJPVMGBUCF-XVFCMESISA-N

Gene Information

mouse ... Uck1(22245)

Description

General description

Uridine is a pyrimidine nucleoside which is crucial for the synthesis of RNA and membranes. It helps in normal cell function and growth by forming pyrimidine nucleotide -lipid conjugates.

Application

Uridine has been used to study the functional complementation of nucleoside hydrolase from a protozoan parasite and mammalian uridine phosphorylase on URH1 (uridine hydrolase) of Saccharomyces cerevisiae.
It has been used to check the effect of chronic uridine application on liver metabolism in mice.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Saccharomyces cerevisiae URH1 (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase.

Mitterbauer R, et al.

Applied and Environmental Microbiology, 68, 1336-1343 (2002)

Purinergic and Pyrimidinergic Signalling: Molecular, Nervous and Urogenitary System Function

Handbook of Experimental Pharmacology (2013)

Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice.

Urasaki Y, et al.

PLoS ONE, 11, e0146994-e0146994 (2016)

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Global Trade Item Number

SKU	GTIN
U6381-5G	04061837409851
U6381-25G	04061833632581