U6628
Uvaol
≥95%
Synonym(s):
Urs-12-ene-3,28-diol
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About This Item
Empirical Formula (Hill Notation):
C30H50O2
CAS Number:
Molecular Weight:
442.72
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352103
EC Number:
208-888-3
MDL number:
Quality Level
assay
≥95%
mp
223-225 °C (lit.)
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
SMILES string
C[C@@H]1CC[C@]2(CO)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C
InChI
1S/C30H50O2/c1-19-10-15-30(18-31)17-16-28(6)21(25(30)20(19)2)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h8,19-20,22-25,31-32H,9-18H2,1-7H3/t19-,20+,22+,23-,24+,25+,27+,28-,29-,30-/m1/s1
InChI key
XUARCIYIVXVTAE-ZAPOICBTSA-N
Gene Information
mouse ... Nos2(18126)
General description
Uvaolis a pentacyclic triterpene compound usually extracted from plant leaves such as Apocynum venetum L., olive leaves (Olea europaea L.), and oregano (Origanum vulgare L.).
Application
Uvaol has been used as retinoic acid receptor-related orphan receptor gamma t (RORγt) inhibitor to study the role of cardiac glycoside reductase 2 (Cgr2) enzyme on its metabolism.
Biochem/physiol Actions
Uvaolexerts pharmacological properties such as antioxidant, anticancer, anti-inflammatory, and wound healing. It also displays vasodilator, hepatoprotective, and antimicrobial effects. Uvaol has inhibitory effects on nitric oxide (NO) release.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Emad M Hassan et al.
Planta medica, 74(14), 1749-1750 (2008-11-01)
Phytochemical investigation of the methanolic extract of Plumeria acutifolia (Apocynaceae) leaves has led to the isolation and identification by spectroscopic means of a new monoterpene alkaloid, (R)-4'-((S)-1-hydroxyethyl)-5,6-dihydro-5' H-spiro[cyclopenta[C]pyridine-7,2'-furan)-5'-one, for which the name plumerianine was adopted, the iridoid 15-demethylplumeride, and three
Lei Liu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 32(17), 1762-1765 (2007-11-13)
To investigate the chemical constituents of Pyrola calliatha. The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data. Ten compounds were isolated and identified as chimaphilin (1), uvaol(2), ursolic acid (3), 2beta,3beta,23-trihydroxy-12-ene-28-ursolic acid
B S Min et al.
Planta medica, 65(4), 374-375 (1999-06-12)
The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 micrograms/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol
Global Trade Item Number
| SKU | GTIN |
|---|---|
| U6628-25MG | 04061837409929 |