UC167
Oxidized Nifedipine
powder, ~95% (HPLC)
Synonym(s):
2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester
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About This Item
Empirical Formula (Hill Notation):
C17H16N2O6
CAS Number:
Molecular Weight:
344.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
assay
~95% (HPLC)
Quality Level
form
powder
color
yellow
mp
100-105 °C
storage temp.
2-8°C
SMILES string
COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O
InChI
1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
InChI key
UMQHJQGNGLQJPF-UHFFFAOYSA-N
Application
Oxidized Nifedipine may be used:
- to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
- as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
- in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)
Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.
Biochem/physiol Actions
CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.
Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| UC167-5MG | 04061832931739 |
| UC167-10MG | 04061832931722 |