V4640
VU0357017 monohydrochloride
≥98% (HPLC)
Synonym(s):
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride, CID 25010775, ML071 hydrochloride, SID 56353039
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About This Item
Empirical Formula (Hill Notation):
C18H27N3O3 · HCl
CAS Number:
Molecular Weight:
369.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c2ccccc2C
InChI
1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H
InChI key
XKJQVUIXSBOCPP-UHFFFAOYSA-N
Biochem/physiol Actions
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist.
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
Carolin Gall et al.
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Andreia N Horácio et al.
PloS one, 8(9), e73704-e73704 (2013-09-26)
In Portugal, pneumococcal conjugate vaccines have been administered to children outside of the national immunization plan since 2001. We determined the serotype and antimicrobial susceptibility of 1265 isolates responsible for adult invasive pneumococcal infections (IPD) between 2009 and 2011 and
Masayuki Ikeno et al.
The International journal of oral & maxillofacial implants, 28(5), e283-e289 (2013-09-26)
The objective of this pilot study was to histologically evaluate bone regeneration using a self-assembling peptide hydrogel scaffold with recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rabbit calvaria model. Five adult New Zealand White rabbits were used for the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| V4640-25MG | 04061832078212 |
| V4640-5MG | 04061832078229 |