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X4879

Xaliproden hydrochloride

Name: Xaliproden hydrochloride
Brand: SIGMA

≥97% (HPLC), solid

Synonym(s):

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride, SR-57746A

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₂F₃N · HCl

CAS Number:

90494-79-4

Molecular Weight:

417.89

NACRES:

NA.77

PubChem Substance ID:

329830807

UNSPSC Code:

12352200

MDL number:

MFCD00896209

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥97% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

SMILES string

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

InChI key

WVHBEIJGAINUBW-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

Description

Biochem/physiol Actions

5-HT_1A serotonin receptor agonist; neuroprotectant

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

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Serotonin Receptors

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SR 57746A/xaliproden, a non-peptide neurotrophic compound: prospects and constraints for the treatment of nervous system diseases.

Marc Porzner et al.

Expert opinion on investigational drugs, 18(11), 1765-1772 (2009-10-10)

Neurodegenerative disorders such as Alzheimer's disease or amyotrophic lateral sclerosis as well as peripheral neuropathies are difficult to treat due to a limited range of effective drugs. Neurotrophic growth factors promote neuronal survival and differentiation and could hence be interesting

SR 57746A attenuates cytostatic drug-induced reduction of neurite outgrowth in co-cultures of rat dorsal root ganglia and Schwann cells.

G S Ruigt et al.

Neuroscience letters, 203(1), 9-12 (1996-01-12)

A co-culture system of intact rat dorsal root ganglia (DRG) with Schwann cells was used to evaluate the potential neurotrophic activity of SR 57746A. Neuritogenesis from DRG was measured with an image analysis system following exposure to different concentrations of

Xaliproden lessens oxaliplatin-mediated neuropathy.

Ed Susman

The Lancet. Oncology, 7(4), 288-288 (2006-04-08)

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Global Trade Item Number

SKU	GTIN
X4879-25MG	04061832086439
X4879-5MG	04061837549793