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Z0153

ZM 241385

Name: ZM 241385
Brand: SIGMA

≥98% (HPLC), adenosine A2A antagonist, powder

Synonym(s):

4-(-2-[7-amino-2-{2-furyl}{1,2,4}triazolo{2,3-a} {1,3,5}triazin-5-yl-amino]ethyl)phenol

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₅N₇O₂

CAS Number:

139180-30-6

Molecular Weight:

337.34

UNSPSC Code:

12352200

PubChem Substance ID:

329831597

NACRES:

NA.77

MDL number:

MFCD00908394

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

ZM 241385, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: >15 mg/mL

storage temp.

room temp

SMILES string

Nc1nc(NCCc2ccc(O)cc2)nc3nc(nn13)-c4ccco4

InChI

1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)

InChI key

PWTBZOIUWZOPFT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ZM 241385 is a potent selective adenosine A2A antagonist.

ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Adenosine Receptors

We offers many products related to adenosine receptors for your research needs.

The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2.

Krystyna Gołembiowska et al.

Neurotoxicity research, 22(2), 150-157 (2012-03-13)

It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that

Number of Circulating CD 73-Expressing Lymphocytes Correlates With Survival After Cardiac Arrest.

Sergey Ryzhov et al.

Journal of the American Heart Association, 8(13), e010874-e010874 (2019-06-27)

Background Patients resuscitated from cardiac arrest ( CA ) have highly variable neurological, circulatory, and systemic ischemia-reperfusion injuries. After the initial hypoxic-ischemic insult, a cascade of immune and inflammatory responses develops and is often fatal. The role of the immune

The anti-tumor effect of A3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cells.

Fabrizio Vincenzi et al.

PloS one, 7(6), e39317-e39317 (2012-07-05)

A(3) adenosine receptors (ARs) play a pivotal role in the development of cancer and their activation is involved in the inhibition of tumor growth. The effects of pulsed electromagnetic fields (PEMFs) on cancer have been controversially discussed and the detailed

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Global Trade Item Number

SKU	GTIN
Z0153-25MG	04061832078366
Z0153-5MG	04061837588419