Z4277
Zileuton
≥98% (HPLC), 5-Lipoxygenase inhibitor, powder
Synonym(s):
(±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea
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About This Item
Empirical Formula (Hill Notation):
C11H12N2O2S
CAS Number:
Molecular Weight:
236.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Zileuton, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥20 mg/mL at ~60 °C (warm up to 60 C for 5min)
originator
Abbott
storage temp.
room temp
SMILES string
CC(N(O)C(N)=O)c1cc2ccccc2s1
InChI
1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
InChI key
MWLSOWXNZPKENC-UHFFFAOYSA-N
Gene Information
human ... ALOX5(240)
Biochem/physiol Actions
Zileuton is a 5-Lipoxygenase inhibitor.
Zileuton is an anti-asthmatic, an inhibitor of 5-lipoxygenase; the initial enzyme in the biosynthesis of leukotrienes from arachidonic acid.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Discover Bioactive Small Molecules for Lipid Signaling Research
Norwin Kubick et al.
Molecules (Basel, Switzerland), 25(9) (2020-05-10)
Repurposing drugs to target M1 macrophages inflammatory response in depression constitutes a bright alternative for commonly used antidepressants. Depression is a significant type of mood disorder, where patients suffer from pathological disturbances associated with a proinflammatory M1 macrophage phenotype. Presently
Ju Youn Lee et al.
Nature communications, 11(1), 2358-2358 (2020-05-14)
Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer's disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) is first generated
M Bessadóttir et al.
Prostaglandins, leukotrienes, and essential fatty acids, 98, 39-47 (2015-05-13)
Lipoxygenases (LOXs) and their products are involved in several biological functions and have been associated with carcinogenesis. Protolichesterinic acid (PA), a lichen metabolite, inhibits 5- and 12-LOX and has anti-proliferative effects on various cancer cell lines. Here, PA was shown
Global Trade Item Number
| SKU | GTIN |
|---|---|
| Z4277-10MG | 04061837626074 |
| Z4277-50MG | 04061832787374 |