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Merck
CN

47783

(±)-α-Tocopherol

analytical standard

Synonym(s):

DL-all-rac-α-Tocopherol, Vitamin E

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About This Item

Empirical Formula (Hill Notation):
C29H50O2
CAS Number:
Molecular Weight:
430.71
UNSPSC Code:
12164500
E Number:
E307
PubChem Substance ID:
EC Number:
233-466-0
Beilstein/REAXYS Number:
94012
MDL number:
NACRES:
NA.24
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grade

analytical standard

form

liquid

CofA

current certificate can be downloaded

feature

standard type fat soluble vitamin

packaging

ampule of 100 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

density

0.950 g/mL at 20 °C (lit.)

application(s)

food and beverages

format

neat

storage temp.

-10 to -25°C

SMILES string

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

InChI key

GVJHHUAWPYXKBD-UHFFFAOYSA-N

General description

α-Tocopherol is a form of fat-soluble vitamin E and shows anti-oxidant, anti-inflammatory, anti-cell proliferative, and anti-cancer properties.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

Application

The analytical standard can also be used as follows:

  • Simultaneous determination of vitamin A and all four tocopherol isomers in human serum samples by ultra-high performance liquid chromatography (UHPLC) combined with fluorescence detection following their liquid-liquid extraction (LLE)
  • Multi-residue analysis of vitamin B (B1, B2, B5, and B9), and vitamin E (α-tocopherol, β-tocopherol, α-tocotrienol, and β-tocotrienol) in grass and grain samples of four different wheat varieties by liquid chromatography-electrospray ionization/multistage mass spectrometry (LC-ESI-MS/MS)
  • Separation and estimation of four tocopherols and four tocotrienols in pecan nut cultivar samples using non-aqueous reversed-phase high-performance liquid chromatography (NARP-HPLC) coupled with atmospheric pressure chemical ionization-tandem mass spectrometric (APCI-MS/MS) detection
  • Analysis of different cold pressed oil samples to detect and quantify eight tocol- homologs using a chemometrically-assisted optimized high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) based method
  • Multi-residue determination of tocopherols in aromatic peanut oil (APO) and four refined vegetable oils using high-performance liquid chromatography with UV detection to detect adulteration

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

ppe

Eyeshields, Gloves



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Protocols

Separation of (±)-α-Tocopherol, analytical standard; Menadione (K3), analytical standard; (+)-γ-Tocopherol, analytical standard; Cholecalciferol (D3), analytical standard

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.


Simultaneous determination of retinol, ?-tocopherol and ?-carotene in serum by isocratic high-performance liquid chromatography
Arnaud.J, et al.
Journal of Chromatography. B, Biomedical Applications, 572(1-2), 103-116 (1991)
Simultaneous determination of plasma retinol, alpha-tocopherol, lycopene, alpha-carotene, and beta-carotene by high-performance liquid chromatography.
Miller WK, et al.
Analytical Biochemistry, 138(2), 340-345 (1984)
George Gachumi et al.
Molecules (Basel, Switzerland), 26(5) (2021-04-04)
Phytosterols and tocopherols are commonly used in food and pharmaceutical industries for their health benefits. Current analysis methods rely on conventional liquid chromatography, using an analytical column, which can be tedious and time consuming. However, simple, and fast analytical methods



Global Trade Item Number

SKUGTIN
4778304061835560851