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47858

Thiamine Hydrochloride (B1)

analytical standard

Synonym(s):

Thiamine hydrochloride, Aneurine hydrochloride, Vitamin B1 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H17ClN4OS · HCl
CAS Number:
67-03-8
Molecular Weight:
337.27
EC Number:
200-641-8
UNSPSC Code:
12164500
PubChem Substance ID:
24871525
Beilstein/REAXYS Number:
3851771
MDL number:
MFCD00012780
NACRES:
NA.24
eCl@ss:
34058006
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Quality Level

100

grade

analytical standard

CofA

current certificate can be downloaded

feature

standard type water soluble vitamin

packaging

ampule of 1000 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

250 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

format

neat

storage temp.

2-30°C

SMILES string

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

General description

Thiamine hydrochloride (B1) is a water soluble vitamin, which belongs the B-complex group of vitamins. It can exist both as a hemihydrate and as a nonstoichiometric hydrate. It can generally act like a co-enzyme for biochemical reactions involved in carbohydrate metabolism.

Application

Thiamine Hydrochloride (B1) may be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography (HPLC) technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD0313
LC26581V
LC25887V
LC25292V
LC24910V

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Protocols

LC/MS/MS Analysis of Vitamins B1 and B6 on Ascentis® Express OH5

Separation of Pyridoxine Hydrochloride (B6), analytical standard; Thiamine Hydrochloride (B1), analytical standard

Insights into the dehydration behavior of thiamine hydrochloride (Vitamin B1) hydrates: Part II
Chakravarty P, et al.
Journal of Pharmaceutical Sciences, 99(4), 1882-1895 (2010)
Wanamaker.PB and Massey K
Applied Pharmacology for Veterinary Technicians, (5) (2014)
High-performance liquid chromatography method for the simultaneous determination of thiamine hydrochloride, pyridoxine hydrochloride and cyanocobalamin in pharmaceutical formulations using coulometric electrochemical and ultraviolet detection
Marszall LM, et al.
Journal of Chromatography A, 1094(1-2), 91-98 (2005)
View All Related Papers

Global Trade Item Number

SKUGTIN
CDS008234-100MG04061828969692
4785804061835560875