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Merck
CN

PHL89788

Scutellarin

phyproof® Reference Substance

Synonym(s):

4′,5,6,7-Tetrahydroxyflavone 7-glucuronide, 5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl-β-D-glucopyranosiduronic acid, 7-(β-D-Glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Breviscapin, Scutellarein-7-O-β-D-glucuronide

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About This Item

Empirical Formula (Hill Notation):
C21H18O12
CAS Number:
Molecular Weight:
462.36
NACRES:
NA.24
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
71779
MDL number:
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grade

primary reference standard

product line

phyproof® Reference Substance

assay

≥95.0% (HPLC)

form

solid

manufacturer/tradename

PhytoLab

SMILES string

O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H]1O)C(O)=O)Oc2cc3OC(=CC(=O)c3c(O)c2O)c4ccc(O)cc4

InChI

1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1

InChI key

DJSISFGPUUYILV-ZFORQUDYSA-N

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Neuroprotectant, angiogenesis promoter
Scutellarin is a flavonoid that exhibits a number of cardio- and neuro-protective effects. Scutellarin inhibits p38 activity, ERK phosphorylation, and TGF-β expression and fibrosis in a rat myocardial infarct model. In a cerebral ischemia-reperfusion model, the compound reduced infarct volume and neurological deficits by increasing eNOS expression while inhibiting the induction of iNOS.

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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