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1370270

USP

Loratadine

Name: Loratadine
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₃N₂O₂Cl

CAS Number:

79794-75-5

Molecular Weight:

382.88

NACRES:

NA.24

PubChem Substance ID:

329750256

UNSPSC Code:

41116107

MDL number:

MFCD00672869

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Properties

grade

pharmaceutical primary standard

API family

loratadine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Loratadine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Loratadine Capsules
Loratadine Chewable Tablets
Loratadine Oral Solution
Loratadine Orally Disintegrating Tablets
Loratadine Tablets

Biochem/physiol Actions

Non-sedating histamine H₁-receptor antagonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Loratadine in the treatment of urticaria.

E W Monroe

Clinical therapeutics, 19(2), 232-242 (1997-03-01)

Urticaria is a common skin disease, which in its chronic form, is a very disturbing condition. Because histamine is the best-documented chemical mediator of urticaria, histamine-antagonists are the mainstay of therapy. First-generation antihistamines are limited by their tendency to produce

Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders.

M Haria et al.

Drugs, 48(4), 617-637 (1994-10-01)

Loratadine is a long-acting antihistamine agent, exhibiting partial selectivity for peripheral histamine H1-receptors. To date, loratadine has been evaluated in allergic rhinitis, urticaria and, to a limited extent, in asthma. In several large controlled comparative clinical studies, loratadine was superior

Safety and efficacy of loratadine in urticaria.