V900422
Folic acid
Vetec™, reagent grade, ≥97%
Synonym(s):
PteGlu, Pteroyl-L-glutamic acid, Vitamin M
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About This Item
Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
Molecular Weight:
441.40
EC Number:
200-419-0
UNSPSC Code:
12352106
PubChem Substance ID:
Beilstein/REAXYS Number:
100781
MDL number:
grade
reagent grade
product line
Vetec™
assay
≥97%
form
powder
technique(s)
HPLC: suitable
color
yellow to orange
mp
>285 °C
SMILES string
NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
InChI
1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChI key
OVBPIULPVIDEAO-LBPRGKRZSA-N
General description
Folic acid belongs to vitamin B group and is also called as vitamin B9 or folate. It is present as 5-methyltetrahydrofolate in humans. Grains, fruits and vegetables are dietary sources of folate. Pteroylmonoglutamate is a synthetic folate which comprises single glutamate and exists in the oxidized state.
Biochem/physiol Actions
Folic acid is essential for cell growth, brain functioning and plays a key role on serine production from glycine. It also coordinates with vitamin B12 in maintaining iron levels. Deficiency of folate is implicated in megaloblastic anemia. Folic acid aids in the repair and synthesis of DNA. Dietary supplementation and fortification of folate in foods is recommended for pregnant women especially in the first trimester to avoid congenital malformation and neural tube defects (NTDs). However, folate fortification may also impose a moderate risk of developing prostate cancer. Supplementation of folate to colon cancer cells diminishes iron levels and impairs the cell division.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
wgk
WGK 1
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Folic acid supplementation for pregnant women and those planning pregnancy: 2015 update
Chitayat D, et al.
Journal of Clinical Pharmacology, 56(2), 170-175 (2016)
High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells
Pellis L, et al.
The British Journal of Nutrition, 99(4), 703-708 (2008)
Cancer risk with folic acid supplements: a systematic review and meta-analysis
Wien TN, et al.
BMJ Open, 2(1), e000653-e000653 (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| V900422-100G | 04061833470008 |
| V900422-25G | 04061833470015 |